Gonna be honest here and take the route that's not politically correct. I have found that males are generally better at pvp and winning games. This is probably because of psychological differences, such as focus, spatial awareness, reaction time, competitiveness, and more. If you were to compare the stats of 100 random females and 100 random males and average their ratios, you would see what I'm talking about.
Whenever I fight females, I usually find that they are in general much easier. I know that's probably sexist, but it's an correlation I have come to notice. So yes, gender does matter. I think that in any mental or physical pursuit, gender does matter, since gender always has an impact on how you think. It shows in every sport, game, and field.